VETEXPERT Hepatiale Forte Advanced 30 Tablets

VETEXPERT Hepatiale Forte Advanced 30 Tablets - Product description

Hepatiale Forte Advanced is a rich formulation, comprehensively supporting liver function and recovery and regeneration of hepatocytes (liver cells). It has been developed for dogs and cats with suspected liver disease, as well as diagnosed liver inflammation or intoxication and impaired or stagnant bile secretion.

Composition

• L-ornithine aspartate
• Soy lecithin (as a source of phospholipids)
• Magnesium stearate

Composition analysis

• The manufacturer does not provide a compositional analysis of the product.

Extras

• Methionine in the form of S-Adenosylmethionine
• Thistle seed extract Silybum marianum (L.)
• Zinc oxide

Dosage

Dogs - 1 tablet per 10 kg body weight
Cats - half a tablet per cat

Administer before or during meals. Tablets should be administered whole or crushed. If the daily dose is several tablets can be divided into 2-3 portions. The animal must have permanent access to fresh water.

The manufacturer does not limit the age or size of the animal.

Additional information

Phospholipids, which are glycerol esters of cholinophosphoric acid and the unsaturated fatty acids linoleic, linolenic and oleic, have a protective and regenerative effect on liver cells. Phospholipids, due to their content of polyunsaturated fatty acids in the side chains, cannot be synthesised in the body. When supplied to the body, they are incorporated into the cell membranes and cytoplasmic membranes of liver cells (hepatocytes), replenishing losses caused by disease processes. This results in faster regeneration of damaged liver cells and restoration of their normal function. This improves the function of membrane receptors, membrane enzyme systems and active and passive transport processes. Phospholipids are essential for liver cell differentiation and proliferation. They inhibit fibrotic processes in liver tissue by decreasing collagen production and increasing the activity of the collagen-degrading enzyme collagenase. Phospholipids, along with bile acids, play an important role in the digestion of fats and the absorption of the vitamins dissolved in them.

S-adenosyl-methionine (SAM) is an endogenous substance formed when the adenosyl group of adenosine 5-triphosphate (ATP) is attached to the sulphur atom of methionine. Its concentration decreases in the course of many liver diseases. SAM is involved in a number of metabolic processes, but its most important role is in the transmethylation reaction, i.e. the transfer of the -CH3 group, which is necessary for the synthesis of cell membrane phospholipids. In addition, SAM is actively involved in trans-sulfuration reactions, necessary for the synthesis in the liver of the natural antioxidant glutathione, and in aminopropylation, which is a step in the synthesis of polyamines that stimulate the synthesis of DNA, protein and proteoglycans, necessary for the growth and regeneration of liver cells. It is particularly recommended as an adjunct in the treatment of toxic liver poisoning and bile stasis. It can be used as a shielding agent during long-term steroid use and after paracetamol poisoning in cats.

Milk thistle extract (Silybum marianum) contains silymarin, or a group of four flavonolignans - silibinin, silydiamine, silicristin and isosylibinin - as active substances. Sylibin has the highest biological activity. The main mechanisms of action of silymarin in the liver are antioxidant and anti-inflammatory effects, achieved by inhibiting lipid oxidase activity and leukotriene synthesis. It may also have a cholagogic and shielding effect in cases of poisoning. Silymarin is a safe and non-toxic compound, recommended for poisoning as well as chronic liver inflammation. The combination of silybin with phospholipids has a particularly strong protective effect on the liver.

Ornithine regulates the urea cycle in dogs and cats. It is involved in the conversion of ammonia formed from the breakdown of amino acids into urea, reducing its level of toxicity. Ornithine plays a special role in cats, which also use amino acids for energy production. Their deamination processes are very intensive, making ornithine essential for them. Ornithine is recommended for the treatment of cats suffering from, or suspected of suffering from, hepatic encephalopathy and those that have not taken food for a long time.

Zinc, is a component of many enzymes that regulate the metabolism of nucleic acids, carbohydrates, promote wound healing, growth and reproduction. In the case of liver disorders, the use of zinc reduces the absorption of copper from the gastrointestinal tract, which is an element with a strong toxic effect on the liver. In other words, zinc protects the liver from excess copper and may also act as an antioxidant. In patients with liver disease, it is recommended to increase its amount in the diet.